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Vaginal flora – friend or foe? Spoiler: it can be both.

Hüvelyflóra – barát vagy ellenség? Spoiler: mindkettő lehet.

The overwhelming majority of women experience vaginal complaints at least once in their lives – burning sensations, itching, unusual discharge, and, of course, the eternal question: "Shouldn't I get a culture done?" Vaginal discharge culture is often the first diagnostic step, but unfortunately, it does not always lead to a definitive answer.

The female vagina is a complex, living ecosystem. Lactobacilli – such as L. crispatus, L. iners, or L. gasseri – form the backbone of a healthy flora. These microscopic guardians create an acidic environment that prevents the proliferation of pathogens and also regulates the local immune response. Yet, the vaginal flora of women is diverse: not everyone lives with a "classic" Lactobacillus dominance, and this does not necessarily mean there is a problem.

In fact, Candida fungus, for instance, can be detected in 60% of women – without it causing any complaints. Gardnerella, a well-known player in bacterial vaginosis, is also a frequent guest. Their presence, therefore, does not necessarily mean trouble. If we culture vaginal discharge, a microorganism can easily "grow out" that is indeed present but is not actually responsible for the symptoms. This is like a security camera recording someone at a scene – it doesn't mean they committed the offense.

Vaginal discharge culture is therefore a delicate genre: it can be misleading and lead to unnecessary treatments. At the same time, there are pathogens – such as Chlamydia – that are never part of a healthy vaginal flora, so if they appear, they indicate a real problem.

The bottom line? The vaginal flora is not black and white. Diagnosis always requires a combined interpretation of symptoms, age, cycle phase, and test results – not just a "positive culture." Let us trust in our bodies, and even more so: in professionals who see not just the bacteria, but us as a complex whole.

References:

  1. Petrova MI, van den Broek M, Balzarini J, Vanderleyden J, Lebeer S. The role of Lactobacillus iners in vaginal health and disease. Frontiers in Cellular and Infection Microbiology. 2020;10:76. doi:10.3389/fcimb.2020.00076  https://pubmed.ncbi.nlm.nih.gov/34881196/
  2. Ma, B., Forney, L. J., & Ravel, J. (2012). Vaginal microbiome: Rethinking health and disease. Annual Review of Microbiology, 66, 371–389 https://pubmed.ncbi.nlm.nih.gov/22746335/
  3. Sobel, J. D. (2007). Vulvovaginal candidosis. The Lancet, 369(9577), 1961–1971. https://pubmed.ncbi.nlm.nih.gov/17560449/ 
  4. Muzny CA, Schwebke JR. Pathogenesis of bacterial vaginosis: discussion of current hypotheses. Journal of Infectious Diseases. 2016 Nov 15;214(suppl 1):S1-S5. doi:10.1093/infdis/jiw119 https://pubmed.ncbi.nlm.nih.gov/27449868/

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